Comparative Genomics

Produktbeschreibung

As genome-sequencing costs continue their downward spiral, sequencing of closely related organisms has become increasingly a?ordable. The growing amount of genomic data available demands for the constant development of computational tools to be applied in comparative genomics. The RECOMB Workshop on C- parative Genomics (RECOMB-CG) is devoted to bringing together scientists working on all aspects of comparative genomics, from computer scientists, ma- ematicians and statisticians working on novel computational approaches for genome analysis and comparison, to biologists applying these computational tools to study the structure and the evolution of prokaryotic and eukaryotic genomes. This volume contains the 19 papers presented at the 7th Annual RECOMB-CG workshop held during September 27¿29, 2009 at the Renyi Institute, in Budapest, Hungary. The papers published in these proceedings were selected for oral p- sentation from 31 submissions from scientists around the world. Each paper was reviewed by at least three members of the Program Committee in a stringent and thoughtful peer-review process. 

Inhaltsverzeichnis

Yeast Ancestral Genome Reconstructions: The Possibilities of Computational
Methods.- Natural Parameter Values for Generalized Gene Adjacency.- Parking
Functions, Labeled Trees and DCJ Sorting Scenarios.- Counting All DCJ Sorting
Scenarios.- Minimal Conflicting Sets for the Consecutive Ones Property in
Ancestral Genome Reconstruction.- Finding Nested Common Intervals Efficiently.-
DCJ Median Problems on Linear Multichromosomal Genomes: Graph Representation and
Fast Exact Solutions.- Rearrangement Models and Single-Cut Operations.- Aligning
Two Genomic Sequences That Contain Duplications.- Inferring the Recent
Duplication History of a Gene Cluster.- Pseudo Boolean Programming for Partially
Ordered Genomes.- Computing the Summed Adjacency Disruption Number between Two
Genomes with Duplicate Genes Using Pseudo-Boolean Optimization.- Reconstructing
Histories of Complex Gene Clusters on a Phylogeny.- Co-evolutionary Models for
Reconstructing Ancestral Genomic Sequences: Computational Issues and Biological
Examples.- Whole-Genome Analysis of Gene Conversion Events.- A Statistically
Fair Comparison of Ancestral Genome Reconstructions, Based on Breakpoint and
Rearrangement Distances.- Comparative Genomics and Extensive Recombinations in
Phage Communities.- Properties of Sequence Conservation in Upstream Regulatory
and Protein Coding Sequences among Paralogs in Arabidopsis thaliana.-
Transcription Factor Binding Probabilities in Orthologous Promoters: An
Alignment-Free Approach to the Inference of Functional Regulatory Targets.