PORTO-
FREI

HIV-1 Latency

von Springer-Verlag GmbH

This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.04 Molecular Control of HIV and SIV Latency.- Assays to Measure Latency, Reservoirs and Reactivation.- The Antiviral Immune Response and its Impact on the HIV-1 Reservoir.- Nonhuman Primate Models for Studies of AIDS Virus Persistence During Suppressive Combination Antiretroviral Therapy.- SIV Latency in Macrophages in the CNS.- Mathematical models of HIV latency.- Residual Immune Activation and Latency.- Immune Interventions to Eliminate the HIV Reservoir.- Cell and Gene Therapy for HIV Cure.

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Produktbeschreibung


This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.04
Molecular Control of HIV and SIV Latency.- Assays to Measure Latency, Reservoirs and Reactivation.- The Antiviral Immune Response and its Impact on the HIV-1 Reservoir.- Nonhuman Primate Models for Studies of AIDS Virus Persistence During Suppressive Combination Antiretroviral Therapy.- SIV Latency in Macrophages in the CNS.- Mathematical models of HIV latency.- Residual Immune Activation and Latency.- Immune Interventions to Eliminate the HIV Reservoir.- Cell and Gene Therapy for HIV Cure. 

Autoreninfo


Guido Silvestri


Emory University School of Medicine, Atlanta, GA 30329, USA

gsilves@emory.edu


Mathias Lichterfeld

The Brigham and Women's Hospital and the Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA

MLICHTERFELD@mgh.harvard.edu
 

Produktdetails

Medium: Buch
Format: Gebunden
Seiten: vii, 248
Sprache: Englisch
Erschienen: Dezember 2018
Auflage: 2019
Sonstiges: .978-3-030-02815-2
Maße: 244 x 164 mm
Gewicht: 536 g
ISBN-10: 3030028151
ISBN-13: 9783030028152
Verlagsbestell-Nr.: 978-3-030-02815-2

Bestell-Nr.: 24943046 
Bestell-Nr. Verlag: 978-3-030-02815-2

LIBRI: 2076106
LIBRI-EK*: 100.09 € (23.00%)
LIBRI-VK: 139,09 €
Libri-STOCK: 3
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P_SALEALLOWED: WORLD
DRM: 0
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1 = PDF Wasserzeichen
2 = DRM Adobe
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UVP: 2 
Warengruppe: 16930 

KNO: 73496445
KNO-EK*: 87.66 € (25.00%)
KNO-VK: 139,09 €
KNV-STOCK: 0

KNO-SAMMLUNG: Current Topics in Microbiology and Immunology .417
P_ABB: Bibliographie
KNOABBVERMERK: 1st ed. 2018. 2018. vii, 248 S. 235 mm
KNOSONSTTEXT: .978-3-030-02815-2
KNOMITARBEITER: Herausgegeben von Silvestri, Guido; Lichterfeld, Mathias
Einband: Gebunden
Auflage: 2019
Sprache: Englisch
Beilage(n): Book

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